5ONE
Crystal structure of Aurora-A in complex with FMF-03-145-1 (compound 2)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Aurora kinase A | polymer | 285 | 32948.8 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (Human) | Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
2 | A | 4-(propanoylamino)-~{N}-[4-[(5,8,11-trimethyl-6-oxidanylidene-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]benzamide | non-polymer | 535.6 | 1 | Chemie (9YQ) | |||
3 | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 122 - 403 (UniProt: O14965)
PDB | External Database | Details |
---|---|---|
Gly 119 | - | expression tag |
Ala 120 | - | expression tag |
Met 121 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 32948.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 535.6 | |
All* | Total formula weight | 33484.4 |