5OJM

Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25

Summary for 5OJM

Entry DOI	10.2210/pdb5ojm/pdb
Descriptor	Human GABAA receptor chimera beta3-alpha5,Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit alpha-5, Nanobody Nb25, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	gabaa receptor, nanobody complex, neurosteroid, ion channel, membrane protein
Biological source	synthetic construct More
Total number of polymer chains	10
Total formula weight	296516.39
Authors	Miller, P.S.,Scott, S.,Masiulis, S.,De Colibus, L.,Pardon, E.,Steyaert, J.,Aricescu, A.R. (deposition date: 2017-07-21, release date: 2017-10-04, Last modification date: 2024-01-17)
Primary citation	Miller, P.S.,Scott, S.,Masiulis, S.,De Colibus, L.,Pardon, E.,Steyaert, J.,Aricescu, A.R. Structural basis for GABAA receptor potentiation by neurosteroids. Nat. Struct. Mol. Biol., 24:986-992, 2017 Cited by PubMed: 28991263 DOI: 10.1038/nsmb.3484 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation