5OJM

Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25

5OJM の概要

• エントリーDOI: 10.2210/pdb5ojm/pdb
• 分子名称: Human GABAA receptor chimera beta3-alpha5,Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit alpha-5, Nanobody Nb25, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: gabaa receptor, nanobody complex, neurosteroid, ion channel, membrane protein
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 296516.39

構造登録者

Miller, P.S.,Scott, S.,Masiulis, S.,De Colibus, L.,Pardon, E.,Steyaert, J.,Aricescu, A.R. (登録日: 2017-07-21, 公開日: 2017-10-04, 最終更新日: 2024-01-17)

• 主引用文献: Miller, P.S.,Scott, S.,Masiulis, S.,De Colibus, L.,Pardon, E.,Steyaert, J.,Aricescu, A.R.; Structural basis for GABAA receptor potentiation by neurosteroids.; Nat. Struct. Mol. Biol., 24:986-992, 2017; PubMed: 28991263; DOI: 10.1038/nsmb.3484

実験手法

X-RAY DIFFRACTION (3.3 Å)