5OFA

Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation T424R

5OFA の概要

分子名称MORC family CW-type zinc finger protein 2, ZINC ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
機能のキーワードghkl atpase, chromatin remodeler, epigenetic silencing, transcriptional repressor, coiled-coil, cw domain, dna binding protein, charcot-marie-tooth disease, spinal muscular atrophy, nuclear protein
由来する生物種Homo sapiens (Human)
ポリマー鎖数2
分子量合計141342.01
構造登録者
Douse, C.H.,Liu, Y.,Modis, Y. (登録日: 2017-07-10, 公開日: 2018-02-14, 最終更新日: 2018-08-08)
主引用文献
Douse, C.H.,Bloor, S.,Liu, Y.,Shamin, M.,Tchasovnikarova, I.A.,Timms, R.T.,Lehner, P.J.,Modis, Y.
Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
Nat Commun, 9:651-651, 2018
PubMed: 29440755 (主引用文献が同じPDBエントリー)
DOI: 10.1038/s41467-018-03045-x
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.57 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24130.1%6.7%4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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