5OEW

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with glutamate and positive allosteric modulator BPAM538

Summary for 5OEW

Entry DOI	10.2210/pdb5oew/pdb
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, ZINC ION, ... (6 entities in total)
Functional Keywords	ionotropic glutamate receptor glua2. ligand-binding domain, positive allosteric modulator, membrane protein
Biological source	Rattus norvegicus (Rat) More
Cellular location	Cell membrane ; Multi-pass membrane protein : P19491
Total number of polymer chains	3
Total formula weight	90318.51
Authors	Larsen, A.P.,Frydenvang, K.A.,Kastrup, J.S. (deposition date: 2017-07-10, release date: 2018-01-03, Last modification date: 2024-01-17)
Primary citation	Goffin, E.,Drapier, T.,Larsen, A.P.,Geubelle, P.,Ptak, C.P.,Laulumaa, S.,Rovinskaja, K.,Gilissen, J.,Tullio, P.,Olsen, L.,Frydenvang, K.,Pirotte, B.,Hanson, J.,Oswald, R.E.,Kastrup, J.S.,Francotte, P. 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. J. Med. Chem., 61:251-264, 2018 Cited by PubMed: 29256599 DOI: 10.1021/acs.jmedchem.7b01323 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation