5OEW

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with glutamate and positive allosteric modulator BPAM538

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue GLU A 301

Chain	Residue
A	TYR61
A	HOH434
A	HOH442
A	HOH447
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 302

Chain	Residue
A	GLU42
A	HIS46
A	HOH546
C	GLU166

---

site_id	AC3
Number of Residues	1
Details	binding site for residue ZN A 303

Chain	Residue
A	ASP126

---

site_id	AC4
Number of Residues	2
Details	binding site for residue ZN A 304

Chain	Residue
A	HOH407
A	HOH411

---

site_id	AC5
Number of Residues	3
Details	binding site for residue ACT A 305

Chain	Residue
A	ASP216
A	SER217
B	ASP248

---

site_id	AC6
Number of Residues	26
Details	binding site for residue 9TE B 901

Chain	Residue
A	LYS104
A	PRO105
A	PHE106
A	MET107
A	SER108
A	SER217
A	LYS218
A	GLY219
A	ASN242
A	LEU247
A	HOH416
A	HOH470
A	HOH553
A	HOH554
B	LYS104
B	PRO105
B	PHE106
B	MET107
B	SER108
B	SER217
B	LYS218
B	GLY219
B	ASN242
B	LEU247
B	HOH1053
B	HOH1069

---

site_id	AC7
Number of Residues	13
Details	binding site for residue GLU B 902

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	GLU193
B	HOH1015
B	HOH1043
B	HOH1061

---

site_id	AC8
Number of Residues	5
Details	binding site for residue ZN B 903

Chain	Residue
B	GLU42
B	LYS45
B	HIS46
B	HOH1063
B	HOH1140

---

site_id	AC9
Number of Residues	2
Details	binding site for residue ZN B 904

Chain	Residue
B	ASP139
B	HOH1017

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN B 905

Chain	Residue
B	ASP156
B	HOH1052
B	HOH1124
B	HOH1133

---

site_id	AD2
Number of Residues	3
Details	binding site for residue ZN B 906

Chain	Residue
B	ASP65
B	ACT909
B	HOH1122

---

site_id	AD3
Number of Residues	2
Details	binding site for residue ZN B 907

Chain	Residue
B	HIS46
B	HOH1158

---

site_id	AD4
Number of Residues	2
Details	binding site for residue ZN B 908

Chain	Residue
B	HOH1006
B	HOH1007

---

site_id	AD5
Number of Residues	4
Details	binding site for residue ACT B 909

Chain	Residue
B	ASP65
B	ASP67
B	ZN906
B	HOH1008

---

site_id	AD6
Number of Residues	18
Details	binding site for residue 9TE C 301

Chain	Residue
C	HOH402
C	HOH403
C	LYS104
C	PRO105
C	PRO105
C	PHE106
C	PHE106
C	MET107
C	MET107
C	SER108
C	SER217
C	LYS218
C	LYS218
C	GLY219
C	ASN242
C	ASN242
C	LEU247
C	HOH401

---

site_id	AD7
Number of Residues	12
Details	binding site for residue GLU C 302

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	GLY141
C	SER142
C	THR143
C	GLU193
C	HOH433
C	HOH467
C	HOH484

---

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN C 303

Chain	Residue
C	HIS46
C	HOH510
C	HOH580
C	HOH584

---

site_id	AD9
Number of Residues	3
Details	binding site for residue ZN C 304

Chain	Residue
C	ASP156
C	HOH415
C	HOH578

---

site_id	AE1
Number of Residues	3
Details	binding site for residue ZN C 305

Chain	Residue
C	HIS23
C	GLU30
C	ACT312

---

site_id	AE2
Number of Residues	4
Details	binding site for residue ZN C 306

Chain	Residue
C	GLU42
C	HIS46
C	LEU241
C	HOH422

---

site_id	AE3
Number of Residues	2
Details	binding site for residue ZN C 307

Chain	Residue
C	HOH407
C	HOH458

---

site_id	AE4
Number of Residues	2
Details	binding site for residue ZN C 308

Chain	Residue
C	ASP126
C	HOH525

---

site_id	AE5
Number of Residues	1
Details	binding site for residue ZN C 309

Chain	Residue
C	GLU132

---

site_id	AE6
Number of Residues	2
Details	binding site for residue ZN C 310

Chain	Residue
C	HOH404
C	HOH421

---

site_id	AE7
Number of Residues	3
Details	binding site for residue ACT C 311

Chain	Residue
C	ARG180
C	SER184
C	LYS187

---

site_id	AE8
Number of Residues	5
Details	binding site for residue ACT C 312

Chain	Residue
C	LYS20
C	HIS23
C	GLU30
C	ZN305
C	HOH480

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3

---