5OCJ

Crystal structure of Ag85C bound to cyclophostin 8beta inhibitor

Summary for 5OCJ

Entry DOI	10.2210/pdb5ocj/pdb
Descriptor	Diacylglycerol acyltransferase/mycolyltransferase Ag85C, methoxy-[(3~{R})-3-[(2~{R})-1-methoxy-1,3-bis(oxidanylidene)butan-2-yl]pentadecyl]phosphinic acid, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	ag85c, mycolicate, mycomembrane, tmm, tdm, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Cellular location	Secreted : P9WQN9
Total number of polymer chains	2
Total formula weight	67482.88
Authors	Viljoen, A.,Richard, M.,Nguyen, P.C.,Spilling, C.D.,Canaan, S.,Cavalier, J.F.,Blaise, M.,Kremer, L. (deposition date: 2017-07-03, release date: 2018-01-24, Last modification date: 2024-01-17)
Primary citation	Viljoen, A.,Richard, M.,Nguyen, P.C.,Fourquet, P.,Camoin, L.,Paudal, R.R.,Gnawali, G.R.,Spilling, C.D.,Cavalier, J.F.,Canaan, S.,Blaise, M.,Kremer, L. Cyclipostins and cyclophostin analogs inhibit the antigen 85C from J. Biol. Chem., 293:2755-2769, 2018 Cited by PubMed: 29301937 DOI: 10.1074/jbc.RA117.000760 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation