5OC7
Crystal structure of the pleckstrin-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-PH_4).
Summary for 5OC7
Entry DOI | 10.2210/pdb5oc7/pdb |
Descriptor | Breakpoint cluster region protein,pleckstrin-homology domain of Bcr-Abl, monobody Mb(Bcr-PH_4), GLYCEROL, ... (5 entities in total) |
Functional Keywords | pleckstrin-homology, monobody, bcr-abl, phosphoinositide-binding, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 51536.44 |
Authors | Reckel, S.,Reynaud, A.,Pojer, F.,Hantschel, O. (deposition date: 2017-06-29, release date: 2017-12-27, Last modification date: 2024-01-17) |
Primary citation | Reckel, S.,Gehin, C.,Tardivon, D.,Georgeon, S.,Kukenshoner, T.,Lohr, F.,Koide, A.,Buchner, L.,Panjkovich, A.,Reynaud, A.,Pinho, S.,Gerig, B.,Svergun, D.,Pojer, F.,Guntert, P.,Dotsch, V.,Koide, S.,Gavin, A.C.,Hantschel, O. Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat Commun, 8:2101-2101, 2017 Cited by PubMed: 29235475DOI: 10.1038/s41467-017-02313-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.652 Å) |
Structure validation
Download full validation report