5OAI

Structure of MDM2 with low molecular weight inhibitor

5OAI の概要

• エントリーDOI: 10.2210/pdb5oai/pdb
• 分子名称: E3 ubiquitin-protein ligase Mdm2, 3-[(1~{R})-2-(~{tert}-butylamino)-1-[methanoyl-[[3,4,5-tris(fluoranyl)phenyl]methyl]amino]-2-oxidanylidene-ethyl]-6-chloranyl-1~{H}-indole-2-carboxylic acid (3 entities in total)
• 機能のキーワード: p53, mdm2, mdmx, protein-protein interaction, cancer, inhibitor, ligase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11895.25

構造登録者

Twarda-Clapa, A.,Neochoritis, C.G.,Grudnik, P.,Dubin, G.,Domling, A.,Holak, T.A. (登録日: 2017-06-22, 公開日: 2019-02-13, 最終更新日: 2024-01-17)

• 主引用文献: Skalniak, L.,Twarda-Clapa, A.,Neochoritis, C.G.,Surmiak, E.,Machula, M.,Wisniewska, A.,Labuzek, B.,Ali, A.M.,Krzanik, S.,Dubin, G.,Groves, M.,Domling, A.,Holak, T.A.; A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53wtosteosarcoma cells.; Febs J., 286:1360-1374, 2019; PubMed: 30715803; DOI: 10.1111/febs.14774

実験手法

X-RAY DIFFRACTION (2 Å)