5O7I

ERK5 in complex with a pyrrole inhibitor

Summary for 5O7I

• Entry DOI: 10.2210/pdb5o7i/pdb
• Descriptor: Mitogen-activated protein kinase 7, 4-(2-bromanyl-6-fluoranyl-phenyl)carbonyl-~{N}-pyridin-3-yl-1~{H}-pyrrole-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, pyrrole, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 41523.56

Authors

Tucker, J.A.,Heptinstall, A.,Myers, S. (deposition date: 2017-06-08, release date: 2018-06-20, Last modification date: 2024-01-17)

• Primary citation: Myers, S.M.,Miller, D.C.,Molyneux, L.,Arasta, M.,Bawn, R.H.,Blackburn, T.J.,Cook, S.J.,Edwards, N.,Endicott, J.A.,Golding, B.T.,Griffin, R.J.,Hammonds, T.,Hardcastle, I.R.,Harnor, S.J.,Heptinstall, A.B.,Lochhead, P.A.,Martin, M.P.,Martin, N.C.,Newell, D.R.,Owen, P.J.,Pang, L.C.,Reuillon, T.,Rigoreau, L.J.M.,Thomas, H.D.,Tucker, J.A.,Wang, L.Z.,Wong, A.C.,Noble, M.E.M.,Wedge, S.R.,Cano, C.; Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38 alpha and BRD4.; Eur.J.Med.Chem., 178:530-543, 2019; PubMed: 31212132; DOI: 10.1016/j.ejmech.2019.05.057

Experimental method

X-RAY DIFFRACTION (2.38 Å)