5O7I
ERK5 in complex with a pyrrole inhibitor
Summary for 5O7I
Entry DOI | 10.2210/pdb5o7i/pdb |
Descriptor | Mitogen-activated protein kinase 7, 4-(2-bromanyl-6-fluoranyl-phenyl)carbonyl-~{N}-pyridin-3-yl-1~{H}-pyrrole-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, pyrrole, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41523.56 |
Authors | Tucker, J.A.,Heptinstall, A.,Myers, S. (deposition date: 2017-06-08, release date: 2018-06-20, Last modification date: 2024-01-17) |
Primary citation | Myers, S.M.,Miller, D.C.,Molyneux, L.,Arasta, M.,Bawn, R.H.,Blackburn, T.J.,Cook, S.J.,Edwards, N.,Endicott, J.A.,Golding, B.T.,Griffin, R.J.,Hammonds, T.,Hardcastle, I.R.,Harnor, S.J.,Heptinstall, A.B.,Lochhead, P.A.,Martin, M.P.,Martin, N.C.,Newell, D.R.,Owen, P.J.,Pang, L.C.,Reuillon, T.,Rigoreau, L.J.M.,Thomas, H.D.,Tucker, J.A.,Wang, L.Z.,Wong, A.C.,Noble, M.E.M.,Wedge, S.R.,Cano, C. Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38 alpha and BRD4. Eur.J.Med.Chem., 178:530-543, 2019 Cited by PubMed: 31212132DOI: 10.1016/j.ejmech.2019.05.057 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
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