5O76

Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant

5O76 の概要

分子名称E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, UbV.pCBL ubiquitin variant, ... (6 entities in total)
機能のキーワードe3 ring ligase, ubiquitin variant, ligase
由来する生物種Homo sapiens (Human)
詳細
細胞内の位置Cytoplasm P22681
ポリマー鎖数6
分子量合計111580.85
構造登録者
Gabrielsen, M.,Buetow, L.,Huang, D.T. (登録日: 2017-06-08, 公開日: 2017-11-01, 最終更新日: 2018-01-24)
主引用文献
Gabrielsen, M.,Buetow, L.,Nakasone, M.A.,Ahmed, S.F.,Sibbet, G.J.,Smith, B.O.,Zhang, W.,Sidhu, S.S.,Huang, D.T.
A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68:456-470.e10, 2017
PubMed: 29053960 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.molcel.2017.09.027
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.473 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25910.4%3.4%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード