5O6J

Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-1031

Summary for 5O6J

Entry DOI	10.2210/pdb5o6j/pdb
Related	5MU6 5O6H
Descriptor	Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, PHOSPHATE ION, ... (6 entities in total)
Functional Keywords	myristoyl, transferase, inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	94351.99
Authors	Brannigan, J.A.,Wilkinson, A.J. (deposition date: 2017-06-06, release date: 2018-05-16, Last modification date: 2024-01-17)
Primary citation	Mousnier, A.,Bell, A.S.,Swieboda, D.P.,Morales-Sanfrutos, J.,Perez-Dorado, I.,Brannigan, J.A.,Newman, J.,Ritzefeld, M.,Hutton, J.A.,Guedan, A.,Asfor, A.S.,Robinson, S.W.,Hopkins-Navratilova, I.,Wilkinson, A.J.,Johnston, S.L.,Leatherbarrow, R.J.,Tuthill, T.J.,Solari, R.,Tate, E.W. Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Nat Chem, 10:599-606, 2018 Cited by PubMed: 29760414 DOI: 10.1038/s41557-018-0039-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation