5O4O
HER3 in complex with Fab MF3178
Summary for 5O4O
Entry DOI | 10.2210/pdb5o4o/pdb |
Descriptor | MF3178 FAB light chain, MF3178 FAB heavy chain, Receptor tyrosine-protein kinase erbB-3, ... (5 entities in total) |
Functional Keywords | her3 ectodomain, complex, fab, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 3 |
Total formula weight | 123600.23 |
Authors | De Nardis, C.,Gros, P. (deposition date: 2017-05-30, release date: 2018-05-16, Last modification date: 2024-01-17) |
Primary citation | Geuijen, C.A.W.,De Nardis, C.,Maussang, D.,Rovers, E.,Gallenne, T.,Hendriks, L.J.A.,Visser, T.,Nijhuis, R.,Logtenberg, T.,de Kruif, J.,Gros, P.,Throsby, M. Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade. Cancer Cell, 33:922-936.e10, 2018 Cited by PubMed: 29763625DOI: 10.1016/j.ccell.2018.04.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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