5O4A

Human FGF in complex with a covalent inhibitor

Summary for 5O4A

Entry DOI	10.2210/pdb5o4a/pdb
Descriptor	Fibroblast growth factor receptor 1, SULFATE ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	fgfr fibroblast growth factor, covalent inhibition, fgfr fibroblast grwth fctr rtk, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains	2
Total formula weight	71613.87
Authors	Debreczeni, J.,Breed, J.,Mukherjee, H.,Aquila, B.,Kaiser, C.,Tentarelli, S.,Whitty, A.,Grimster, N. (deposition date: 2017-05-26, release date: 2018-02-07)
Primary citation	Mukherjee, H.,Debreczeni, J.,Breed, J.,Tentarelli, S.,Aquila, B.,Dowling, J.E.,Whitty, A.,Grimster, N.P. A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions. Org. Biomol. Chem., 15:9685-9695, 2017 Cited by PubMed: 29119993 DOI: 10.1039/c7ob02028g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation