5O45
Structure of human PD-L1 in complex with inhibitor
Summary for 5O45
Entry DOI | 10.2210/pdb5o45/pdb |
Descriptor | Programmed cell death 1 ligand 1, PHE-MEA-9KK-SAR-ASP-VAL-MEA-TYR-SAR-TRP-TYR-LEU-CCS-GLY-NH2 (3 entities in total) |
Functional Keywords | pd-1, programmed death 1, pd-l1, programmed death ligand 1, immune checkpoint, cancer, cell cycle |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform 1: Cell membrane ; Single-pass type I membrane protein . Isoform 2: Endomembrane system ; Single-pass type I membrane protein : Q9NZQ7 |
Total number of polymer chains | 2 |
Total formula weight | 16605.96 |
Authors | Magiera, K.,Grudnik, P.,Dubin, G.,Holak, T.A. (deposition date: 2017-05-26, release date: 2017-09-20, Last modification date: 2024-01-17) |
Primary citation | Magiera-Mularz, K.,Skalniak, L.,Zak, K.M.,Musielak, B.,Rudzinska-Szostak, E.,Kocik, J.,Grudnik, P.,Sala, D.,Zarganes-Tzitzikas, T.,Shaabani, S.,Domling, A.,Dubin, G.,Holak, T.A. Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint. Angew. Chem. Int. Ed. Engl., 56:13732-13735, 2017 Cited by PubMed: 28881104DOI: 10.1002/anie.201707707 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.99 Å) |
Structure validation
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