5O42
17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal 2,6-pyridinketone inhibitor.
Summary for 5O42
| Entry DOI | 10.2210/pdb5o42/pdb |
| Descriptor | 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... (6 entities in total) |
| Functional Keywords | non-steroidal inhibitor, 17beta-hsd14, oxidoreductase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 29874.62 |
| Authors | Bertoletti, N.,Heine, A.,Braun, F.,Klebe, G.,Marchais-Oberwinkler, S. (deposition date: 2017-05-25, release date: 2018-06-06, Last modification date: 2024-01-17) |
| Primary citation | Braun, F.,Bertoletti, N.,Moller, G.,Adamski, J.,Frotscher, M.,Guragossian, N.,Madeira Girio, P.A.,Le Borgne, M.,Ettouati, L.,Falson, P.,Muller, S.,Vollmer, G.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. Structure-based design and profiling of novel 17 beta-HSD14 inhibitors. Eur J Med Chem, 155:61-76, 2018 Cited by PubMed: 29859505DOI: 10.1016/j.ejmech.2018.05.029 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
Download full validation report
