5O2Z
Domain swap dimer of the G167R variant of gelsolin second domain
Summary for 5O2Z
Entry DOI | 10.2210/pdb5o2z/pdb |
Related | 1KCQ 5FAE 5FAF |
Descriptor | Gelsolin, CALCIUM ION, CITRATE ANION, ... (7 entities in total) |
Functional Keywords | amyloidosis, gelsolin, 3d domain swap, dimer, pathological mutant, structural protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 27248.10 |
Authors | Boni, F.,Milani, M.,Mastrangelo, E.,de Rosa, M. (deposition date: 2017-05-23, release date: 2017-11-08, Last modification date: 2024-01-17) |
Primary citation | Boni, F.,Milani, M.,Barbiroli, A.,Diomede, L.,Mastrangelo, E.,de Rosa, M. Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein. Hum. Mol. Genet., 27:53-65, 2018 Cited by PubMed: 29069428DOI: 10.1093/hmg/ddx383 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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