5O2Z

Domain swap dimer of the G167R variant of gelsolin second domain

Summary for 5O2Z

Entry DOI	10.2210/pdb5o2z/pdb
Related	1KCQ 5FAE 5FAF
Descriptor	Gelsolin, CALCIUM ION, CITRATE ANION, ... (7 entities in total)
Functional Keywords	amyloidosis, gelsolin, 3d domain swap, dimer, pathological mutant, structural protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	27248.10
Authors	Boni, F.,Milani, M.,Mastrangelo, E.,de Rosa, M. (deposition date: 2017-05-23, release date: 2017-11-08, Last modification date: 2024-01-17)
Primary citation	Boni, F.,Milani, M.,Barbiroli, A.,Diomede, L.,Mastrangelo, E.,de Rosa, M. Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein. Hum. Mol. Genet., 27:53-65, 2018 Cited by PubMed: 29069428 DOI: 10.1093/hmg/ddx383 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation