5O2B

Crystal structure of WNK3 kinase domain in a diphosphorylated state and in a complex with the inhibitor PP-121

Summary for 5O2B

• Entry DOI: 10.2210/pdb5o2b/pdb
• Descriptor: Serine/threonine-protein kinase WNK3, 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, SODIUM ION, ... (4 entities in total)
• Functional Keywords: wnk3, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 65971.46

Authors

Pinkas, D.M.,Bufton, J.C.,Newman, J.A.,Borkowska, O.,Chalk, R.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2017-05-19, release date: 2017-06-28, Last modification date: 2019-10-16)

• Primary citation: Pinkas, D.M.,Daubner, G.M.,Bufton, J.C.,Bartual, S.G.,Sanvitale, C.E.,Alessi, D.R.,Bullock, A.; Crystal structure of WNK3 kinase domain in a diphosphorylated state and in a complex with the inhibitor PP-121; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.038 Å)