5O2B
Crystal structure of WNK3 kinase domain in a diphosphorylated state and in a complex with the inhibitor PP-121
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Serine/threonine-protein kinase WNK3 | polymer | 285 | 32654.9 | 2 | UniProt (Q9BYP7) Pfam (PF00069) In PDB | Homo sapiens (Human) | Protein kinase lysine-deficient 3,Protein kinase with no lysine 3 |
| 2 | A, B | 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | non-polymer | 319.4 | 2 | Chemie (KS1) | |||
| 3 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | water | water | 18.0 | 252 | Chemie (HOH) |
Sequence modifications
A, B: 132 - 414 (UniProt: Q9BYP7)
| PDB | External Database | Details |
|---|---|---|
| Ser 130 | - | expression tag |
| Met 131 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65309.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 661.7 | |
| All* | Total formula weight | 65971.5 |
