5O1S
Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
Summary for 5O1S
Entry DOI | 10.2210/pdb5o1s/pdb |
Descriptor | Ribosomal protein S6 kinase alpha-3, SODIUM ION, Dimethyl fumarate, ... (4 entities in total) |
Functional Keywords | covalent, inhibitor, kinase, allosteric, transferase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 41557.10 |
Authors | Andersen, J.L.,Nissen, P. (deposition date: 2017-05-19, release date: 2018-05-30, Last modification date: 2024-01-17) |
Primary citation | Andersen, J.L.,Gesser, B.,Funder, E.D.,Nielsen, C.J.F.,Gotfred-Rasmussen, H.,Rasmussen, M.K.,Toth, R.,Gothelf, K.V.,Arthur, J.S.C.,Iversen, L.,Nissen, P. Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases. Nat Commun, 9:4344-4344, 2018 Cited by PubMed: 30341347DOI: 10.1038/s41467-018-06787-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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