5O14
Co-crystal structure of a cross-reactive bactericidal human antibody targeting meningococcal vaccine antigen factor H binding protein
Summary for 5O14
Entry DOI | 10.2210/pdb5o14/pdb |
Descriptor | Factor H binding protein variant 1.1, Fab 1A12 Heavy Chain, Fab 1A12 Light Chain, ... (6 entities in total) |
Functional Keywords | human fab, factor h binding protein, outer membrane, infection, immune system |
Biological source | Neisseria meningitidis serogroup B (strain MC58) More |
Total number of polymer chains | 6 |
Total formula weight | 153920.80 |
Authors | Lopez-Sagaseta, J. (deposition date: 2017-05-18, release date: 2018-02-14, Last modification date: 2024-01-17) |
Primary citation | Lopez-Sagaseta, J.,Beernink, P.T.,Bianchi, F.,Santini, L.,Frigimelica, E.,Lucas, A.H.,Pizza, M.,Bottomley, M.J. Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp. Nat Commun, 9:528-528, 2018 Cited by PubMed: 29410413DOI: 10.1038/s41467-018-02827-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.195 Å) |
Structure validation
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