5NX2

Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution

5NX2 の概要

• エントリーDOI: 10.2210/pdb5nx2/pdb
• 分子名称: Glucagon-like peptide 1 receptor, truncated peptide agonist, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: 7tm, gpcr, signalling protein, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52088.24

構造登録者

Rappas, M.,Jazayeri, A.,Brown, A.J.H.,Kean, J.,Errey, J.C.,Robertson, N.,Fiez-Vandal, C.,Andrews, S.P.,Congreve, M.,Bortolato, A.,Mason, J.S.,Baig, A.H.,Teobald, I.,Dore, A.S.,Weir, M.,Cooke, R.M.,Marshall, F.H. (登録日: 2017-05-09, 公開日: 2017-06-14, 最終更新日: 2024-01-17)

• 主引用文献: Jazayeri, A.,Rappas, M.,Brown, A.J.H.,Kean, J.,Errey, J.C.,Robertson, N.J.,Fiez-Vandal, C.,Andrews, S.P.,Congreve, M.,Bortolato, A.,Mason, J.S.,Baig, A.H.,Teobald, I.,Dore, A.S.,Weir, M.,Cooke, R.M.,Marshall, F.H.; Crystal structure of the GLP-1 receptor bound to a peptide agonist.; Nature, 546:254-258, 2017; PubMed: 28562585; DOI: 10.1038/nature22800

実験手法

X-RAY DIFFRACTION (3.7 Å)