5NWZ
FIBROBLAST GROWTH FACTOR RECEPTOR 4 KINASE DOMAIN (449-753) IN COMPLEX WITH IRREVERSIBLE LIGAND CGA159527
Summary for 5NWZ
Entry DOI | 10.2210/pdb5nwz/pdb |
Descriptor | Fibroblast growth factor receptor 4, ~{N}-[3-[2-(3,5-dimethoxyphenyl)ethyl]-1~{H}-pyrazol-5-yl]-2-(propanoylamino)benzamide (3 entities in total) |
Functional Keywords | hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 69582.34 |
Authors | |
Primary citation | Fairhurst, R.A.,Knoepfel, T.,Leblanc, C.,Buschmann, N.,Gaul, C.,Blank, J.,Galuba, I.,Trappe, J.,Zou, C.,Voshol, J.,Genick, C.,Brunet-Lefeuvre, P.,Bitsch, F.,Graus-Porta, D.,Furet, P. Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region. Medchemcomm, 8:1604-1613, 2017 Cited by PubMed: 30108871DOI: 10.1039/c7md00213k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.37 Å) |
Structure validation
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