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5NQR

Potent inhibitors of NUDT5 silence hormone signaling in breast cancer

Summary for 5NQR
Entry DOI10.2210/pdb5nqr/pdb
DescriptorADP-sugar pyrophosphatase, 8-(dimethylamino)-1,3-dimethyl-7-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]methyl]purine-2,6-dione (3 entities in total)
Functional Keywordsnudix, inhibitor, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : Q9UKK9
Total number of polymer chains2
Total formula weight49897.44
Authors
Carter, M.,Stenmark, P. (deposition date: 2017-04-21, release date: 2018-01-31, Last modification date: 2024-01-17)
Primary citationPage, B.D.G.,Valerie, N.C.K.,Wright, R.H.G.,Wallner, O.,Isaksson, R.,Carter, M.,Rudd, S.G.,Loseva, O.,Jemth, A.S.,Almlof, I.,Font-Mateu, J.,Llona-Minguez, S.,Baranczewski, P.,Jeppsson, F.,Homan, E.,Almqvist, H.,Axelsson, H.,Regmi, S.,Gustavsson, A.L.,Lundback, T.,Scobie, M.,Stromberg, K.,Stenmark, P.,Beato, M.,Helleday, T.
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Nat Commun, 9:250-250, 2018
Cited by
PubMed: 29343827
DOI: 10.1038/s41467-017-02293-7
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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