5NN2

The structure of the polo-box domain (PBD) of Plk1 in complex with Z228588490

Summary for 5NN2

• Entry DOI: 10.2210/pdb5nn2/pdb
• Descriptor: Serine/threonine-protein kinase PLK1, (3~{R},5~{R})-1-[2,4-bis(fluoranyl)phenyl]-5-oxidanyl-pyrrolidine-3-carboxylic acid (3 entities in total)
• Functional Keywords: plk1, pbd1, mitosis, small molecule, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: P53350
• Total number of polymer chains: 1
• Total formula weight: 26998.72

Authors

Kunciw, D.L.,Rossmann, M.,Stokes, J.E.,De Fusco, C.,Spring, D.R.,Hyvonen, M. (deposition date: 2017-04-07, release date: 2018-02-21, Last modification date: 2024-06-19)

• Primary citation: Kunciw, D.L.,De Fusco, C.,Rossmann, M.,Stokes, J.E.,Renzetti, A.,Sore, H.F.,Hyvonen, M.,Spring, D.R.; A fragment-based approach to developing inhibitors of the cryptic pocket of the Polo-Like Kinase 1 Polo-Box Domain.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.81 Å)