5NLB
Crystal structure of human CUL3 N-terminal domain bound to KEAP1 BTB and 3-box
Summary for 5NLB
Entry DOI | 10.2210/pdb5nlb/pdb |
Descriptor | Kelch-like ECH-associated protein 1, Cullin-3 (2 entities in total) |
Functional Keywords | e3 ubiquitin ligase, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 58895.46 |
Authors | Adamson, R.,Krojer, T.,Pinkas, D.M.,Bartual, S.G.,Burgess-Brown, N.A.,Borkowska, O.,Chalk, R.,Newman, J.A.,Kopec, J.,Dixon-Clarke, S.E.,Mathea, S.,Sethi, R.,Velupillai, S.,Mackinnon, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2017-04-04, release date: 2017-04-19, Last modification date: 2024-01-17) |
Primary citation | Adamson, R.J.,Payne, N.C.,Bartual, S.G.,Mazitschek, R.,Bullock, A.N. Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly. Free Radic Biol Med, 204:215-225, 2023 Cited by PubMed: 37156295DOI: 10.1016/j.freeradbiomed.2023.04.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.45 Å) |
Structure validation
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