5NIG

Crystal structure of HLA-DRB1*04:01 with modified alpha-enolase peptide 326-340 (arginine 327 to citrulline)

Summary for 5NIG

Entry DOI	10.2210/pdb5nig/pdb
Related	5NI9
Descriptor	HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-4 beta chain, Alpha-enolase, ... (7 entities in total)
Functional Keywords	hla-dr, enolase, arthritis, citrulline, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	47260.18
Authors	Gerstner, C.,Dubnovitsky, A. (deposition date: 2017-03-24, release date: 2018-06-13, Last modification date: 2024-01-17)
Primary citation	Pieper, J.,Dubnovitsky, A.,Gerstner, C.,James, E.A.,Rieck, M.,Kozhukh, G.,Tandre, K.,Pellegrino, S.,Gebe, J.A.,Ronnblom, L.,Sandalova, T.,Kwok, W.W.,Klareskog, L.,Buckner, J.H.,Achour, A.,Malmstrom, V. Memory T cells specific to citrullinated alpha-enolase are enriched in the rheumatic joint. J. Autoimmun., 92:47-56, 2018 Cited by PubMed: 29853344 DOI: 10.1016/j.jaut.2018.04.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation