5NIG
Crystal structure of HLA-DRB1*04:01 with modified alpha-enolase peptide 326-340 (arginine 327 to citrulline)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 189 | 21911.8 | 1 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (Human) | MHC class II antigen DRA |
| 2 | B (B) | HLA class II histocompatibility antigen, DRB1-4 beta chain | polymer | 198 | 23102.7 | 1 | UniProt (P13760) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911) | Homo sapiens (Human) | MHC class II antigen DRB1*4,DR4 |
| 3 | C (C) | Alpha-enolase | polymer | 15 | 1681.0 | 1 | UniProt (P06733) | Homo sapiens | 2-phospho-D-glycerate hydro-lyase,C-myc promoter-binding protein,Enolase 1,MBP-1,MPB-1,Non-neural enolase,NNE,Phosphopyruvate hydratase,Plasminogen-binding protein |
| 4 | D, G, H (A, C) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 3 | Chemie (MPD) | |||
| 5 | E (B) | UREA | non-polymer | 60.1 | 1 | Chemie (URE) | |||
| 6 | F (B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 7 | I, J, K (A, B, C) | water | water | 18.0 | 414 | Chemie (HOH) |
Sequence modifications
A: 1 - 181 (UniProt: P01903)
B: 1 - 190 (UniProt: P13760)
| PDB | External Database | Details |
|---|---|---|
| Ser 182 | - | expression tag |
| Ser 183 | - | expression tag |
| Ala 184 | - | expression tag |
| Asp 185 | - | expression tag |
| Leu 186 | - | expression tag |
| Val 187 | - | expression tag |
| Pro 188 | - | expression tag |
| Arg 189 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 191 | - | expression tag |
| Ser 192 | - | expression tag |
| Ala 193 | - | expression tag |
| Asp 194 | - | expression tag |
| Leu 195 | - | expression tag |
| Val 196 | - | expression tag |
| Pro 197 | - | expression tag |
| Arg 198 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 46695.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 564.8 | |
| All* | Total formula weight | 47260.2 |
