5NG1

TUBULIN-MTC-zampanolide complex

Summary for 5NG1

Entry DOI	10.2210/pdb5ng1/pdb
Descriptor	Tubulin alpha-1B chain, (2~{Z},4~{E})-~{N}-[(~{S})-oxidanyl-[(1~{S},2~{E},5~{S},11~{R},17~{S},19~{R})-3,11,19-trimethyl-7,13-bis(oxidanylidene)-6,21-dioxabicyclo[15.3.1]henicos-2-en-5-yl]methyl]hexa-2,4-dienamide, GLYCEROL, ... (15 entities in total)
Functional Keywords	cell cycle, tubulin fold, cytoskeleton, microtubule
Biological source	Rattus norvegicus (Norway Rat) More
Cellular location	Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043
Total number of polymer chains	6
Total formula weight	266164.24
Authors	Field, J.J.,Pera, B.,Estevez Gallego, J.,Calvo, E.,Rodriguez-Salarichs, J.,Saez-Calvo, G.,Zuwerra, D.,Jordi, M.,Prota, A.E.,Menchon, G.,Miller, J.H.,Altmann, K.-H.,Diaz, J.F. (deposition date: 2017-03-16, release date: 2017-10-25, Last modification date: 2024-01-17)
Primary citation	Field, J.J.,Pera, B.,Gallego, J.E.,Calvo, E.,Rodriguez-Salarichs, J.,Saez-Calvo, G.,Zuwerra, D.,Jordi, M.,Andreu, J.M.,Prota, A.E.,Menchon, G.,Miller, J.H.,Altmann, K.H.,Diaz, J.F. Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. J. Nat. Prod., 81:494-505, 2018 Cited by PubMed: 29023132 DOI: 10.1021/acs.jnatprod.7b00704 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation