5NG1
TUBULIN-MTC-zampanolide complex
Summary for 5NG1
Entry DOI | 10.2210/pdb5ng1/pdb |
Descriptor | Tubulin alpha-1B chain, (2~{Z},4~{E})-~{N}-[(~{S})-oxidanyl-[(1~{S},2~{E},5~{S},11~{R},17~{S},19~{R})-3,11,19-trimethyl-7,13-bis(oxidanylidene)-6,21-dioxabicyclo[15.3.1]henicos-2-en-5-yl]methyl]hexa-2,4-dienamide, GLYCEROL, ... (15 entities in total) |
Functional Keywords | cell cycle, tubulin fold, cytoskeleton, microtubule |
Biological source | Rattus norvegicus (Norway Rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 266164.24 |
Authors | Field, J.J.,Pera, B.,Estevez Gallego, J.,Calvo, E.,Rodriguez-Salarichs, J.,Saez-Calvo, G.,Zuwerra, D.,Jordi, M.,Prota, A.E.,Menchon, G.,Miller, J.H.,Altmann, K.-H.,Diaz, J.F. (deposition date: 2017-03-16, release date: 2017-10-25, Last modification date: 2024-01-17) |
Primary citation | Field, J.J.,Pera, B.,Gallego, J.E.,Calvo, E.,Rodriguez-Salarichs, J.,Saez-Calvo, G.,Zuwerra, D.,Jordi, M.,Andreu, J.M.,Prota, A.E.,Menchon, G.,Miller, J.H.,Altmann, K.H.,Diaz, J.F. Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. J. Nat. Prod., 81:494-505, 2018 Cited by PubMed: 29023132DOI: 10.1021/acs.jnatprod.7b00704 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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