5NE3
L2 class A serine-beta-lactamase complexed with avibactam
Summary for 5NE3
Entry DOI | 10.2210/pdb5ne3/pdb |
Descriptor | Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide (3 entities in total) |
Functional Keywords | beta-lactamase, carbapenemase, inhibitor, avibactam, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Stenotrophomonas maltophilia K279a |
Total number of polymer chains | 2 |
Total formula weight | 59170.97 |
Authors | Hinchliffe, P.,Calvopina, K.,Spencer, J. (deposition date: 2017-03-09, release date: 2017-09-13, Last modification date: 2024-01-17) |
Primary citation | Calvopina, K.,Hinchliffe, P.,Brem, J.,Heesom, K.J.,Johnson, S.,Cain, R.,Lohans, C.T.,Fishwick, C.W.G.,Schofield, C.J.,Spencer, J.,Avison, M.B. Structural/mechanistic insights into the efficacy of nonclassical beta-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. Mol. Microbiol., 106:492-504, 2017 Cited by PubMed: 28876489DOI: 10.1111/mmi.13831 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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