5N6I

Crystal structure of mouse cGAS in complex with 39 bp DNA

Summary for 5N6I

Entry DOI	10.2210/pdb5n6i/pdb
Descriptor	Cyclic GMP-AMP synthase, DNA (37-MER), DNA (36-MER), ... (4 entities in total)
Functional Keywords	nucleotidyltransferase, cyclic gmp-amp synthase, cgas, dna-binding, activator dna, pattern recognition receptor, innate immune response, viral dna recognition, transferase
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	14
Total formula weight	356809.53
Authors	Andreeva, L.,Kostrewa, D.,Hopfner, K.-P. (deposition date: 2017-02-15, release date: 2017-09-13, Last modification date: 2024-01-17)
Primary citation	Andreeva, L.,Hiller, B.,Kostrewa, D.,Lassig, C.,de Oliveira Mann, C.C.,Jan Drexler, D.,Maiser, A.,Gaidt, M.,Leonhardt, H.,Hornung, V.,Hopfner, K.P. cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders. Nature, 549:394-398, 2017 Cited by PubMed: 28902841 DOI: 10.1038/nature23890 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.6 Å)

Structure validation