5N6I

Crystal structure of mouse cGAS in complex with 39 bp DNA

5N6I の概要

• エントリーDOI: 10.2210/pdb5n6i/pdb
• 分子名称: Cyclic GMP-AMP synthase, DNA (37-MER), DNA (36-MER), ... (4 entities in total)
• 機能のキーワード: nucleotidyltransferase, cyclic gmp-amp synthase, cgas, dna-binding, activator dna, pattern recognition receptor, innate immune response, viral dna recognition, transferase
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 14
• 化学式量合計: 356809.53

構造登録者

Andreeva, L.,Kostrewa, D.,Hopfner, K.-P. (登録日: 2017-02-15, 公開日: 2017-09-13, 最終更新日: 2024-01-17)

• 主引用文献: Andreeva, L.,Hiller, B.,Kostrewa, D.,Lassig, C.,de Oliveira Mann, C.C.,Jan Drexler, D.,Maiser, A.,Gaidt, M.,Leonhardt, H.,Hornung, V.,Hopfner, K.P.; cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.; Nature, 549:394-398, 2017; PubMed: 28902841; DOI: 10.1038/nature23890

実験手法

X-RAY DIFFRACTION (3.6 Å)