5N5M
Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and (R)-3-(2-((isoquinolin-5-ylmethyl)(methyl)carbamoyl)phenyl)pyrrolidin-1-ium
Summary for 5N5M
Entry DOI | 10.2210/pdb5n5m/pdb |
Descriptor | Serine/threonine-protein kinase pim-1, Pimtide, ~{N}-(isoquinolin-5-ylmethyl)-~{N}-methyl-2-[(3~{R})-pyrrolidin-3-yl]benzamide, ... (4 entities in total) |
Functional Keywords | serine threonine kinase, transferase, proto-oncogene, fragment, pim-1, consensus peptide |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 37650.87 |
Authors | Siefker, C.,Heine, A.,Klebe, G. (deposition date: 2017-02-14, release date: 2018-03-07, Last modification date: 2024-01-17) |
Primary citation | Siefker, C.,Heine, A.,Taylor, C.,Kolb, P.,Hardes, K.,Steinmetzer, A.,Klebe, G. A crystallographic fragment study with human Pim-1 kinase to be published, |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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