5N5M

Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and (R)-3-(2-((isoquinolin-5-ylmethyl)(methyl)carbamoyl)phenyl)pyrrolidin-1-ium

5N5M の概要

• エントリーDOI: 10.2210/pdb5n5m/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, Pimtide, ~{N}-(isoquinolin-5-ylmethyl)-~{N}-methyl-2-[(3~{R})-pyrrolidin-3-yl]benzamide, ... (4 entities in total)
• 機能のキーワード: serine threonine kinase, transferase, proto-oncogene, fragment, pim-1, consensus peptide
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37650.87

構造登録者

Siefker, C.,Heine, A.,Klebe, G. (登録日: 2017-02-14, 公開日: 2018-03-07, 最終更新日: 2024-01-17)

• 主引用文献: Siefker, C.,Heine, A.,Taylor, C.,Kolb, P.,Hardes, K.,Steinmetzer, A.,Klebe, G.; A crystallographic fragment study with human Pim-1 kinase; to be published,

実験手法

X-RAY DIFFRACTION (2.21 Å)