5N26

X-ray structure of human heavy chain ferritin in complex with cisplatin

Summary for 5N26

Entry DOI	10.2210/pdb5n26/pdb
Descriptor	Ferritin heavy chain, Cisplatin, bis(azanyl)-chloranyl-oxidanyl-platinum, ... (6 entities in total)
Functional Keywords	ferritin, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	22638.42
Authors	Ferraro, G.,Merlino, A. (deposition date: 2017-02-07, release date: 2017-08-02, Last modification date: 2024-01-17)
Primary citation	Ferraro, G.,Ciambellotti, S.,Messori, L.,Merlino, A. Cisplatin Binding Sites in Human H-Chain Ferritin. Inorg Chem, 56:9064-9070, 2017 Cited by PubMed Abstract: The aim of this work is to identify the cisplatin binding sites on human H-chain ferritin. High-resolution X-ray crystallography reveals that cisplatin binds four distinct protein sites, that is, the side chains of His136 and Lys68, the side chain of His105, the side chain of Cys90 and the side chain of Cys102. These Pt binding sites are compared with those observed for the adduct that cisplatin forms upon encapsulation within horse spleen L-chain ferritin (87% identity with human L-chain ferritin). PubMed: 28737381 DOI: 10.1021/acs.inorgchem.7b01072 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation