5N1B

hPAD4 crystal complex with AFM-14a

Summary for 5N1B

Entry DOI	10.2210/pdb5n1b/pdb
Related	5N0M 5N0Y 5N0Z
Descriptor	Protein-arginine deiminase type-4, SULFATE ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q9UM07
Total number of polymer chains	1
Total formula weight	75612.71
Authors	Beaumont, E.,Kerry, P.,Thompson, P.,Muth, A.,Subramanian, V.,Nagar, M.,Srinath, H.,Clancy, K.,Parelkar, S. (deposition date: 2017-02-06, release date: 2017-05-24, Last modification date: 2017-11-29)
Primary citation	Muth, A.,Subramanian, V.,Beaumont, E.,Nagar, M.,Kerry, P.,McEwan, P.,Srinath, H.,Clancy, K.,Parelkar, S.,Thompson, P.R. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J. Med. Chem., 60:3198-3211, 2017 Cited by PubMed: 28328217 DOI: 10.1021/acs.jmedchem.7b00274 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation