5N18
Second Bromodomain (BD2) from Candida albicans Bdf1 bound to an imidazopyridine (compound 2)
Summary for 5N18
| Entry DOI | 10.2210/pdb5n18/pdb |
| Descriptor | Bromodomain-containing factor 1, 4-[8-methyl-3-[(4-methylphenyl)amino]imidazo[1,2-a]pyridin-2-yl]phenol, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | bromodomain, transcription |
| Biological source | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
| Cellular location | Nucleus : Q5A4W8 |
| Total number of polymer chains | 2 |
| Total formula weight | 25674.16 |
| Authors | Mietton, F.,Ferri, E.,Champleboux, M.,Zala, N.,Maubon, D.,Zhou, Y.,Harbut, M.,Spittler, D.,Garnaud, C.,Courcon, M.,Chauvel, M.,d'Enfert, C.,Kashemirov, B.A.,Hull, M.,Cornet, M.,McKenna, C.E.,Govin, J.,Petosa, C. (deposition date: 2017-02-05, release date: 2017-05-31, Last modification date: 2024-01-17) |
| Primary citation | Mietton, F.,Ferri, E.,Champleboux, M.,Zala, N.,Maubon, D.,Zhou, Y.,Harbut, M.,Spittler, D.,Garnaud, C.,Courcon, M.,Chauvel, M.,d'Enfert, C.,Kashemirov, B.A.,Hull, M.,Cornet, M.,McKenna, C.E.,Govin, J.,Petosa, C. Selective BET bromodomain inhibition as an antifungal therapeutic strategy. Nat Commun, 8:15482-15482, 2017 Cited by PubMed: 28516956DOI: 10.1038/ncomms15482 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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