5MYV
Crystal structure of SRPK2 in complex with compound 1
Summary for 5MYV
Entry DOI | 10.2210/pdb5myv/pdb |
Descriptor | SRSF protein kinase 2,SRSF protein kinase 2, SULFATE ION, 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, ... (5 entities in total) |
Functional Keywords | transferase, kinase, splicing kinase, inhibitor, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: P78362 |
Total number of polymer chains | 4 |
Total formula weight | 183517.59 |
Authors | Chaikuad, A.,Pike, A.C.W.,Savitsky, P.,von Delft, F.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2017-01-29, release date: 2017-05-10, Last modification date: 2024-01-17) |
Primary citation | Batson, J.,Toop, H.D.,Redondo, C.,Babaei-Jadidi, R.,Chaikuad, A.,Wearmouth, S.F.,Gibbons, B.,Allen, C.,Tallant, C.,Zhang, J.,Du, C.,Hancox, J.C.,Hawtrey, T.,Da Rocha, J.,Griffith, R.,Knapp, S.,Bates, D.O.,Morris, J.C. Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem. Biol., 12:825-832, 2017 Cited by PubMed: 28135068DOI: 10.1021/acschembio.6b01048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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