5MY8
Crystal structure of SRPK1 in complex with SPHINX31
Summary for 5MY8
Entry DOI | 10.2210/pdb5my8/pdb |
Descriptor | SRSF protein kinase 1,SRSF protein kinase 1, CITRIC ACID, GLYCEROL, ... (7 entities in total) |
Functional Keywords | transferase, splicing kinase, inhibitor, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cytoplasm: Q96SB4 |
Total number of polymer chains | 1 |
Total formula weight | 45711.33 |
Authors | Chaikuad, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2017-01-25, release date: 2017-05-10, Last modification date: 2024-05-08) |
Primary citation | Batson, J.,Toop, H.D.,Redondo, C.,Babaei-Jadidi, R.,Chaikuad, A.,Wearmouth, S.F.,Gibbons, B.,Allen, C.,Tallant, C.,Zhang, J.,Du, C.,Hancox, J.C.,Hawtrey, T.,Da Rocha, J.,Griffith, R.,Knapp, S.,Bates, D.O.,Morris, J.C. Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem. Biol., 12:825-832, 2017 Cited by PubMed: 28135068DOI: 10.1021/acschembio.6b01048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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