5MY8

Crystal structure of SRPK1 in complex with SPHINX31

5MY8 の概要

• エントリーDOI: 10.2210/pdb5my8/pdb
• 分子名称: SRSF protein kinase 1,SRSF protein kinase 1, CITRIC ACID, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: transferase, splicing kinase, inhibitor, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cytoplasm: Q96SB4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45711.33

構造登録者

Chaikuad, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2017-01-25, 公開日: 2017-05-10, 最終更新日: 2024-05-08)

• 主引用文献: Batson, J.,Toop, H.D.,Redondo, C.,Babaei-Jadidi, R.,Chaikuad, A.,Wearmouth, S.F.,Gibbons, B.,Allen, C.,Tallant, C.,Zhang, J.,Du, C.,Hancox, J.C.,Hawtrey, T.,Da Rocha, J.,Griffith, R.,Knapp, S.,Bates, D.O.,Morris, J.C.; Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.; ACS Chem. Biol., 12:825-832, 2017; PubMed: 28135068; DOI: 10.1021/acschembio.6b01048

実験手法

X-RAY DIFFRACTION (1.7 Å)