X-ray structure of the F14'A mutant of GLIC in complex with propofol

Summary for 5MUR

DescriptorProton-gated ion channel, ACETATE ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywordsmembrane protein, transport protein
Biological sourceGloeobacter violaceus (strain PCC 7421)
Total number of polymer chains5
Total molecular weight185384.48
Sauguet, L.,Fourati, Z.,Delarue, M. (deposition date: 2017-01-13, release date: 2018-02-14, Last modification date: 2019-10-16)
Primary citation
Fourati, Z.,Howard, R.J.,Heusser, S.A.,Hu, H.,Ruza, R.R.,Sauguet, L.,Lindahl, E.,Delarue, M.
Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.
Cell Rep, 23:993-1004, 2018
PubMed: 29694907 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2018.03.108
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21430 3.0% 0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-21