5MU6

Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and IMP-1088 inhibitor bound

Summary for 5MU6

• Entry DOI: 10.2210/pdb5mu6/pdb
• Related: 4C2Y 4C2Z
• Descriptor: Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: n-myristoylation, inhibitor, rhinovirus capsule assembly, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 94186.52

Authors

Perez-Dorado, I.,Bell, A.S.,Tate, E.W. (deposition date: 2017-01-12, release date: 2018-02-14, Last modification date: 2024-01-17)

• Primary citation: Mousnier, A.,Bell, A.S.,Swieboda, D.P.,Morales-Sanfrutos, J.,Perez-Dorado, I.,Brannigan, J.A.,Newman, J.,Ritzefeld, M.,Hutton, J.A.,Guedan, A.,Asfor, A.S.,Robinson, S.W.,Hopkins-Navratilova, I.,Wilkinson, A.J.,Johnston, S.L.,Leatherbarrow, R.J.,Tuthill, T.J.,Solari, R.,Tate, E.W.; Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.; Nat Chem, 10:599-606, 2018; PubMed: 29760414; DOI: 10.1038/s41557-018-0039-2

Experimental method

X-RAY DIFFRACTION (1.88 Å)