5MQV

Crystal structure of human Casein Kinase I delta in complex with 4-(2,5-Dimethoxyphenyl)-N-(4-(5-(4-fluorphenyl)-2-(methylthio)-1H-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1H-pyrrole-2-carboxamide

Summary for 5MQV

• Entry DOI: 10.2210/pdb5mqv/pdb
• Descriptor: Casein kinase I isoform delta, 4-(2,5-Dimethoxyphenyl)-N-(4-(5-(4-fluorphenyl)-2-(methylthio)-1H-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1H-pyrrole-2-carboxamide, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: ck1d, kinase-inhibitor complex, transferase, kinase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P48730
• Total number of polymer chains: 6
• Total formula weight: 223523.39

Authors

Pichlo, C.,Brunstein, E.,Baumann, U. (deposition date: 2016-12-20, release date: 2017-04-05, Last modification date: 2024-01-17)

• Primary citation: Halekotte, J.,Witt, L.,Ianes, C.,Kruger, M.,Buhrmann, M.,Rauh, D.,Pichlo, C.,Brunstein, E.,Luxenburger, A.,Baumann, U.,Knippschild, U.,Bischof, J.,Peifer, C.; Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1 delta and Their Structural Relation to p38 alpha MAPK.; Molecules, 22:-, 2017; PubMed: 28338621; DOI: 10.3390/molecules22040522

Experimental method

X-RAY DIFFRACTION (2.154 Å)