5MQV
Crystal structure of human Casein Kinase I delta in complex with 4-(2,5-Dimethoxyphenyl)-N-(4-(5-(4-fluorphenyl)-2-(methylthio)-1H-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1H-pyrrole-2-carboxamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Casein kinase I isoform delta | polymer | 314 | 36377.9 | 6 | UniProt (P48730) Pfam (PF00069) In PDB | Homo sapiens (Human) | CKId,Tau-protein kinase CSNK1D |
2 | E, F, A, B, C... | 4-(2,5-Dimethoxyphenyl)-N-(4-(5-(4-fluorphenyl)-2-(methylthio)-1H-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1H-pyrrole-2-carboxamide | non-polymer | 543.6 | 6 | Chemie (D5Q) | |||
3 | D, E, F, A, B... | PHOSPHATE ION | non-polymer | 95.0 | 21 | Chemie (PO4) | |||
4 | water | water | 18.0 | 697 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 294 (UniProt: P48730)
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 218267.3 | |
Non-Polymers* | Number of molecules | 27 |
Total formula weight | 5256.1 | |
All* | Total formula weight | 223523.4 |