5MQ5
A protease-resistant N24S Escherichia coli Asparaginase mutant with outstanding stability and enhanced anti-leukaemic activity
Summary for 5MQ5
| Entry DOI | 10.2210/pdb5mq5/pdb |
| Descriptor | L-asparaginase 2, ASPARTIC ACID (3 entities in total) |
| Functional Keywords | l-asparaginase, amidohydrolase, chemotherapeutic drug, hydrolase |
| Biological source | Escherichia coli |
| Total number of polymer chains | 4 |
| Total formula weight | 142247.05 |
| Authors | Maggi, M.,Mittelman, S.D.,Parmentier, J.H.,Whitmire, J.M.,Merrell, D.S.,Scotti, C. (deposition date: 2016-12-20, release date: 2017-11-15, Last modification date: 2024-01-17) |
| Primary citation | Maggi, M.,Mittelman, S.D.,Parmentier, J.H.,Colombo, G.,Meli, M.,Whitmire, J.M.,Merrell, D.S.,Whitelegge, J.,Scotti, C. A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro. Sci Rep, 7:14479-14479, 2017 Cited by PubMed: 29101342DOI: 10.1038/s41598-017-15075-4 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report
