5MK1

Crystal structure of the His Domain Protein Tyrosine Phosphatase (HD-PTP/PTPN23) Bro1 domain (CHMP4A peptide complex structure)

Summary for 5MK1

Entry DOI	10.2210/pdb5mk1/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 23, Charged multivesicular body protein 4a (3 entities in total)
Functional Keywords	escrt-iii chmp4a, hydrolase
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus: Q9H3S7 Cytoplasmic vesicle membrane: Q9BY43
Total number of polymer chains	8
Total formula weight	171232.84
Authors	Levy, C.,Gahloth, D. (deposition date: 2016-12-02, release date: 2017-08-16, Last modification date: 2024-01-17)
Primary citation	Gahloth, D.,Levy, C.,Walker, L.,Wunderley, L.,Mould, A.P.,Taylor, S.,Woodman, P.,Tabernero, L. Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP. Structure, 25:1011-1024.e4, 2017 Cited by PubMed: 28602823 DOI: 10.1016/j.str.2017.05.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation