5MJB
Kinase domain of human EphB1, G703C mutant, covalently bound to a quinazoline-based inhibitor
Summary for 5MJB
Entry DOI | 10.2210/pdb5mjb/pdb |
Descriptor | Ephrin type-B receptor 1, 2-chloranyl-~{N}-[4-[(2-chloranyl-5-oxidanyl-phenyl)amino]quinazolin-7-yl]ethanamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | receptor tyrosine kinase, kinase domain, inhibitor, covalent, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P54762 |
Total number of polymer chains | 2 |
Total formula weight | 71014.12 |
Authors | Kung, A.,Schimpl, M.,Chen, Y.-C.,Overman, R.C.,Zhang, C. (deposition date: 2016-11-30, release date: 2017-05-17, Last modification date: 2024-01-17) |
Primary citation | Kung, A.,Schimpl, M.,Ekanayake, A.,Chen, Y.C.,Overman, R.,Zhang, C. A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases. ACS Chem. Biol., 12:1499-1503, 2017 Cited by PubMed: 28459525DOI: 10.1021/acschembio.6b01083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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