5MJB

Kinase domain of human EphB1, G703C mutant, covalently bound to a quinazoline-based inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ephrin type-B receptor 1	polymer	305	34903.7	2	UniProt (P54762) Pfam (PF07714)	Homo sapiens (Human)	ELK,EPH tyrosine kinase 2,EPH-like kinase 6,hEK6,Neuronally-expressed EPH-related tyrosine kinase,NET,Tyrosine-protein kinase receptor EPH-2
2	C, G (A, B)	2-chloranyl-~{N}-[4-[(2-chloranyl-5-oxidanyl-phenyl)amino]quinazolin-7-yl]ethanamide	non-polymer		363.2	2	Chemie (7O3)
3	D, E, F, H, I (A, B)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
4	J, K (A, B)	water	water		18.0	220	Chemie (HOH)

Sequence modifications

A, B: 602 - 896 (UniProt: P54762)

PDB	External Database	Details
Met 592	-	initiating methionine
Gly 593	-	expression tag
His 594	-	expression tag
His 595	-	expression tag
His 596	-	expression tag
His 597	-	expression tag
His 598	-	expression tag
His 599	-	expression tag
Gly 600	-	expression tag
Ser 601	-	expression tag
Arg 678	Pro 678	conflict
Cys 703	Gly 703	conflict
Ser 736	Ala 736	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69807.4
Non-Polymers*	Number of molecules	7
	Total formula weight	1206.7
All*	Total formula weight	71014.1

*Water molecules are not included.